Article

Multiple <i>FGFR1</i> mutations modulate tumorigenic mechanisms in glioneuronal tumors

2025-05-28

Abstract excerpt

FGFR1 genetic alterations are associated with human diseases, including brain tumors. We reported multiple FGFR1 mutations in familial and sporadic cases of low-grade glioneuronal tumors, suggesting intrinsic mechanisms of selective pressure toward FGFR1 multiple events arising in the context of a quiet genome. To decipher the molecular mechanisms triggered by multiple FGFR1 mutations, we have mapped the proxim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b39a65cd-cfa0-5a8d-a3b9-bad9c3539836
DOI: 10.1101/2025.05.27.654799

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple <i>FGFR1</i> mutations modulate tumorigenic mechanisms in glioneuronal tumorsDOI 10.1101/2025.05.27.654799Read

Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors.Semantic proximity Read

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomasSemantic proximity Read

A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.Semantic proximity Read

Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.Semantic proximity Read

Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.Semantic proximity Read

FGFR- gene family alterations in low-grade neuroepithelial tumors.Semantic proximity Read

Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomasSemantic proximity Read

Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors.Semantic proximity Read

Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs.Semantic proximity Read

PDGFRA K385 mutants in myxoid glioneuronal tumors promote receptor dimerization and oncogenic signaling.Semantic proximity Read

PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.Semantic proximity Read

PTPN11-Related Noonan Syndrome Predisposes to Multifocal Low-Grade CNS Tumors Harboring FGFR1 VariantsSemantic proximity Read