Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas

12 Jun 2018

Abstract excerpt

Abstract Chordoid glioma (ChG) is a characteristic, slow growing, and well-circumscribed diencephalic tumor, whose mutational landscape is unknown. Here we report the analysis of 16 ChG by whole-exome and RNA-sequencing. We found that 15 ChG harbor the same PRKCA D463H mutation. PRKCA encodes the Protein kinase C (PKC) isozyme alpha (PKCα) and is mutated in a wide range of human cancers. However the hot spot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29915258
DOI: 10.1038/s41467-018-04622-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomasPMID 29915258Read ↗

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricleSemantic proximity Read ↗

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway RewiringSemantic proximity Read ↗

Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring.Semantic proximity Read ↗

PKC signaling in glioblastomaSemantic proximity Read ↗

The complexities of PKCα signaling in cancer.Semantic proximity Read ↗

Non-synonymous SNPs variants of PRKCG and its association with oncogenes predispose to hepatocellular carcinomaSemantic proximity Read ↗

Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapySemantic proximity Read ↗

Comprehensive Analysis Reveals Promising Immune Target and Prognostic Value of PLK3 in GliomaSemantic proximity Read ↗

Origin recognition complex 6 overexpression promotes growth of glioma cellsSemantic proximity Read ↗

Frequent Nek1 overexpression in human gliomasSemantic proximity Read ↗

Influence of PRKCE non-synonymous variants on protein dynamics and functionality.Semantic proximity Read ↗

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.