Article
Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2018
Callender Julia A, Yang Yimin, Lordén Gema, Stephenson Natalie L, Jones Alexander C, Brognard John, Newton Alexandra C
Abstract excerpt
Conventional protein kinase C (PKC) family members are reversibly activated by binding to the second messengers Ca2+ and diacylglycerol, events that break autoinhibitory constraints to allow the enzyme to adopt an active, but degradation-sensitive, conformation. Perturbing these autoinhibitory constraints, resulting in protein destabilization, is one of many mechanisms by which PKC function is lost in cancer....
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