Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenome scans and cancer genome sequencing converge on <i>WNK2</i> , a kinase-independent suppressor of cell growth

19 Jun 2007

Abstract excerpt

Human cancer genome and epigenome projects aim to identify new cancer genes and targets for therapy that have been overlooked by conventional approaches. Here we integrated large-scale genomics and epigenomics of 31 human infiltrative gliomas and identified low-frequency deletion and highly recurrent epigenetic silencing of WNK2, encoding a putative serine/threonine kinase. Prior cancer genome sequencing projects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17578925
DOI: 10.1073/pnas.0700683104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenome scans and cancer genome sequencing converge on <i>WNK2</i> , a kinase-independent suppressor of cell growthPMID 17578925Read ↗

Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.Semantic proximity Read ↗

A new IDH-independent hypermethylation phenotype is associated with astrocyte-like cell state in glioblastomaSemantic proximity Read ↗

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity Read ↗

Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity Read ↗

Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrenceSemantic proximity Read ↗

Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of Notch signalingSemantic proximity Read ↗

Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancersSemantic proximity Read ↗

Frequent Nek1 overexpression in human gliomasSemantic proximity Read ↗

<i>In vivo</i> functional genomics identifies essentiality of potassium homeostasis in medulloblastomaSemantic proximity Read ↗

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.Semantic proximity Read ↗

Integrative Genomic Analysis Identifies <i>NDRG2</i> as a Candidate Tumor Suppressor Gene Frequently Inactivated in Clinically Aggressive MeningiomaSemantic proximity Read ↗

Gliosarcoma: distinct molecular pathways and genomic alterations identified by DNA copy number/SNP microarray analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.