Article
A crystallographic snapshot of tyrosine trans-phosphorylation in action.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2008
Chen Huaibin, Xu Chong-Feng, Ma Jinghong, Eliseenkova Anna V, Li Wanqing, Pollock Pamela M, Pitteloud Nelly, Miller W Todd, Neubert Thomas A, Mohammadi Moosa
Abstract excerpt
Tyrosine trans-phosphorylation is a key event in receptor tyrosine kinase signaling, yet, the structural basis for this process has eluded definition. Here, we present the crystal structure of the FGF receptor 2 kinases caught in the act of trans-phosphorylation of Y769, the major C-terminal phosphorylation site. The structure reveals that enzyme- and substrate-acting kinases engage each other through elaborate...
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