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Article

Hypoxic niche drives lineage imbalance and early tumorigenesis in EGFR-mutant lung cancer.

American journal of respiratory and critical care medicine - 1 Jun 2026

Meng Fanchen, Xia Zhijun, Wang Siwei, Wang Qian, Zhu Meng, You Jing, Wang Qinglin, Shen Ziyang, Sun Qinhong, Li Jianyu, Li Zhitong, Zhu Pengcheng, Sun Yuxiang, Wang Jie, Wang Qianghu, Ma Hongxia, Liu Tongyan, Xu Lin, Yin Rong

Abstract excerpt

RATIONALE: During tumorigenesis, approximately 20% of EGFR-mutant lung adenocarcinomas (LUADs) progress rapidly to aggressive subtypes. Multi-omics analyses of stage I LUAD cohorts have revealed that centrally located lesions exhibit enhanced tumorigenic potential compared with peripheral counterparts, whereas the underlying mechanisms remain elusive. OBJECTIVES: To define the spatial-clinical determinants of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42085227
DOI: 10.1093/ajrccm/aamag150

Genes

EGFR
FOXD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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