Article

Targeting Tumor Heterogeneity and Epithelial-Mesenchymal Plasticity (EMP) by Anti-Hallmark Combinations, Timing, and Sequencing (CTS) Strategy: Theoretical Basis, Hypothesis, and Proposed Protocol

2026-04-29

Abstract excerpt

It has been more than 25 years since the introduction of the Hallmarks of cancer by Hanahan D et al., in which they foresaw cancer research developing into a logical science based on its underlying principles. No doubt, since then, treatment approaches have evolved into personalized medicine, offering excellent benefits to a select patient population. However, three major underlying components of heterotypic inter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c544eb39-56a2-5449-9ac2-fddc6db96723
DOI: 10.20944/preprints202411.1830.v4

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Tumor Heterogeneity and Epithelial-Mesenchymal Plasticity (EMP) by Anti-Hallmark Combinations, Timing, and Sequencing (CTS) Strategy: Theoretical Basis, Hypothesis, and Proposed ProtocolDOI 10.20944/preprints202411.1830.v4Read

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistanceSemantic proximity Read

Epithelial-mesenchymal plasticity—engaging stemness in an interplay of phenotypesSemantic proximity Read

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targetsSemantic proximity Read

Deciphering the Dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in Tumor ProgressionSemantic proximity Read

Update on Epithelial-Mesenchymal Plasticity in Cancer ProgressionSemantic proximity Read

Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Semantic proximity Read

The EMT spectrum and therapeutic opportunities.Semantic proximity Read

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategiesSemantic proximity Read

Dynamics of Epithelial–Mesenchymal Plasticity: What Have Single-Cell Investigations Elucidated So Far?Semantic proximity Read

Epithelial–Mesenchymal Plasticity and Epigenetic Heterogeneity in CancerSemantic proximity Read

Cancer cell plasticity: Impact on tumor progression and therapy response.Semantic proximity Read

Tumor cell plasticity: the challenge to catch a moving target.Semantic proximity Read