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Article

Aging promotes lung cancer metastasis through epigenetic ATF4 induction

2024-07-05

Abstract excerpt

Lung cancer is primarily a disease of the elderly. Despite shared molecular changes between aging and cancer 1 – such as permissive chromatin states and deregulated protein homeostasis – studies on physiologically aged models of human lung cancer are lacking. Here, we show that aging alters the progression of KRAS-driven non-small cell lung cancer (NSCLC), promoting metastasis while suppressing primary lung tumor...

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Literature Corpus work
444c3356-3b6a-52c5-b330-213297300f5d
DOI
10.1101/2024.07.03.601209
Open publication

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Aging promotes lung cancer metastasis through epigenetic ATF4 inductionDOI 10.1101/2024.07.03.601209
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