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Article

PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

11 Feb 2016

Abstract excerpt

Unfolded protein responses (UPR), consisting of three major transducers PERK, IRE1, and ATF6, occur in the midst of a variety of intracellular and extracellular challenges that perturb protein folding in the endoplasmic reticulum (ER). ER stress occurs and is thought to be a contributing factor to a number of human diseases, including cancer, neurodegenerative disorders, and various metabolic syndromes. In the...

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PMID: 26864318
DOI: 10.1002/jcp.25336

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