Article

An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression

2020-12-28

Abstract excerpt

<title>Abstract</title> <p>ATF4 is a major effector of the Integrated Stress Response (ISR), a homeostatic mechanism coupling cell growth and survival to bioenergetic demands. Although the pro-tumorigenic role of the ISR in a tumor cell-intrinsic manner has been established, its role in cell-extrinsic processes remains unexplored. Using novel conditional knockout ATF4 mouse models, we show that global, or fibrobl...

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Literature Corpus work: 8df3b26a-e0be-562d-a109-5ebc1f977504
DOI: 10.21203/rs.3.rs-122088/v1

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