Article

Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure

2019-02-28

Abstract excerpt

The CHARGE Gene-Lifestyle Interactions Working Group is a unique initiative formed to improve our understanding of the role and biological significance of gene-environment interactions in human traits and diseases. The consortium published several multi-ancestry genome-wide interaction studies (GWIS) involving up to 610,475 individuals for three lipids and four blood pressure traits while accounting for interacti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0404591-b7b4-56f9-85d0-9c2b246775b2
DOI: 10.1101/562157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposureDOI 10.1101/562157Read

Gene-lifestyle interactions in the genomics of human complex traits.Semantic proximity Read

An approach to identify gene-environment interactions and reveal new biological insight in complex traits.Semantic proximity Read

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traitsSemantic proximity Read

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits.Semantic proximity Read

Distinct explanations underlie gene-environment interactions in the UK BiobankSemantic proximity Read

Genotype × environment interactions in gene regulation and complex traits.Semantic proximity Read

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.Semantic proximity Read

Distinct explanations underlie gene-environment interactions in the UK Biobank.Semantic proximity Read

Exploring multivariate gene-environment interactions : models and applicationsSemantic proximity Read

Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale.Semantic proximity Read

Gene--environment-wide association studies: emerging approaches.Semantic proximity Read

A cross-population compendium of gene-environment interactions.Semantic proximity Read