A cross-population compendium of gene-environment interactions.

doi:10.1038/s41586-025-10054-6

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Article

A cross-population compendium of gene-environment interactions.

Nature - 1 Mar 2026

Namba Shinichi, Sonehara Kyuto, Koyanagi Yuriko N, Kikuchi Takezo, Ojima Takafumi, Edahiro Ryuya, Sato Go, Yamaji Taiki, Tomofuji Yoshihiko, Ueda Hiroyuki, Yamamoto Kenichi, Ogawa Yosuke, Suzuki Ken, Kanai Akinori, Higashiue Shinichi, Kobayashi Shuzo, Yamaguchi Hiroki, Nagata Yasunobu, Okazaki Yasushi, Matsumoto Naoyuki, Motomura Kenta, Koga Hidenobu, Hishida Asahi, Ikezaki Hiroaki, Hara Megumi, Nagayoshi Mako, Oze Isao, Nakano Shiori, Oda Yoshiya, Suzuki Yutaka, Iwasaki Motoki, Sawada Norie, Matsuo Keitaro, Morisaki Takayuki, Yamauchi Toshimasa, Kadowaki Takashi, Matsuda Koichi, Okada Yukinori

Abstract excerpt

Environmental differences in genetic effect sizes, namely, gene-environment interactions, may uncover the genetic encoding of phenotypic plasticity1-3. We provide a cross-population atlas of gene-environment interactions comprising 440,210 individuals from European and Japanese populations, with replication in 539,794 individuals from diverse populations. By decomposing the contributions from age, sex and...

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PMID: 41606330
DOI: 10.1038/s41586-025-10054-6
PMCID: PMC12999510

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