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Article

Gene--environment-wide association studies: emerging approaches.

Nature reviews. Genetics - 1 Apr 2010

Thomas Duncan

Abstract excerpt

Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene--environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical...

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Identifiers

PMID: 20212493
DOI: 10.1038/nrg2764
PMCID: PMC2891422

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Source receipt: pubmed, retrieved 7 Sept 2026.

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