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Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM<sub>2.5</sub>and Neuropathology Markers of Alzheimer’s Disease

2023-06-30

Abstract excerpt

<h4>INTRODUCTION</h4> Growing evidence indicates fine particulate matter (PM 2.5 ) as risk factor for Alzheimer’s’ disease (AD), but the underlying mechanisms have been insufficiently investigated. We hypothesized differential DNA methylation (DNAm) in brain tissue as potential mediator of this association. <h4>METHODS</h4> We assessed genome-wide DNAm (Illumina EPIC BeadChips) in prefrontal cortex tissue and thre...

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Literature Corpus work
f00124a0-7899-59f4-8d15-dffe282b663b
DOI
10.1101/2023.06.30.23292085
Open publication

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Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM<sub>2.5</sub>and Neuropathology Markers of Alzheimer’s DiseaseDOI 10.1101/2023.06.30.23292085
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