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Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort

2023-04-07

Abstract excerpt

<h4>Introduction</h4> Higher fine particulate matter (PM 2.5 ) exposure has been found to be associated with Alzheimer’s disease (AD). PM 2.5 has been hypothesized to cause inflammation and oxidative stress in the brain, contributing to neuropathology. A major genetic risk factor of AD, the apolipoprotein E ( APOE ) gene, has also been hypothesized to modify the association between PM 2.5 and AD. However, little p...

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Literature Corpus work
80a1ba20-29f1-5508-8b67-fdd96f6049da
DOI
10.1101/2023.04.07.23288288
Open publication

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Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohortDOI 10.1101/2023.04.07.23288288
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