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Article

Association of PM2.5 Exposure and Alzheimer Disease Pathology in Brain Bank Donors-Effect Modification by APOE Genotype.

Neurology - 12 Mar 2024

Christensen Grace M, Li Zhenjiang, Liang Donghai, Ebelt Stefanie, Gearing Marla, Levey Allan I, Lah James J, Wingo Aliza, Wingo Thomas, Hüls Anke

Abstract excerpt

BACKGROUND AND OBJECTIVES: Fine particulate matter (PM2.5) exposure has been found to be associated with Alzheimer disease (AD) and is hypothesized to cause inflammation and oxidative stress in the brain, contributing to neuropathology. The APOE gene, a major genetic risk factor of AD, has been hypothesized to modify the association between PM2.5 and AD. However, little prior research exists to support these...

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Source

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Identifiers

PMID: 38382009
DOI: 10.1212/WNL.0000000000209162
PMCID: PMC13084541

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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