Article
Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.
Neurotoxicity research - 7 Apr 2026
Kimura Kana, Driscoll Ira, Cook Noah, Shahzad Sonia, Betthauser Tobey J, Johnson Sterling C, Asthana Sanjay, Gallagher Catherine L, Hermann Bruce P, Sager Mark A, Blennow Kaj, Zetterberg Henrik, Carlsson Cynthia M, Kollmorgen Gwendlyn, Okonkwo Ozioma C
Abstract excerpt
To determine whether long-term residential air pollution [AP; ozone (O₃) and fine particulate matter (PM₂.₅)] is associated with (1) incident mild cognitive impairment (MCI) or Alzheimer’s disease (AD), (2) biomarkers of core and AD-relevant pathology, and (3) whether these relationships are moderated by APOE4+/- (carrier/non-carrier of one or both ε4 alleles) status or mediated by neuroinflammation. Sample...
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