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The association between cumulative exposure to PM2.5 and DNA methylation measured using methyl-capture sequencing among COPD patients

9 Sept 2024

Abstract excerpt

Abstract Background Particulate matter with a diameter of < 2.5 μm (PM2.5) influences gene regulation via DNA methylation; however, its precise mechanism of action remains unclear. Thus, this study aimed to examine the connection between personal PM2.5 exposure and DNA methylation in CpG islands as well as explore the associated gene pathways. Methods A total of 95 male patients with chronic obstructive pulmonary...

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PMID: 39251997
DOI: 10.1186/s12931-024-02955-3

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