Article

Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub>and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort

2025-04-16

Abstract excerpt

<h4>Introduction</h4> Fine particulate matter (PM 2.5 ) is a known risk factor for Alzheimer’s disease (AD), with emerging evidence linking PM 2.5 exposure to cerebrospinal fluid (CSF) biomarkers in pre-clinical stages. However, the role of DNA methylation (DNAm) as potential mediator in this relationship among cognitively normal individuals remains largely unexplored. <h4>Methods</h4> In 535 cognitively normal in...

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Literature Corpus work: a8f3189a-8905-534c-8eeb-affc42391904
DOI: 10.1101/2025.04.15.25325910

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