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Attenuation of Dopaminergic Neurodegeneration in a <em>C. elegans</em> Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

2023-03-13

Abstract excerpt

Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicat-ed in several neurological disorders, including Parkinson&rsquo;s disease (PD). Here, we report results of an RNAi screen of genes differentially regulated in adr-2 mutants, normally encoding the only catalytically active ADAR in Caenorhabditis elegans, ADR-2. Subsequent analysis of candidate genes that alter the misfolding...

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Literature Corpus work
efe31ec0-855d-5523-a676-6eb29b94fa85
DOI
10.20944/preprints202303.0230.v1
Open publication

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Attenuation of Dopaminergic Neurodegeneration in a <em>C. elegans</em> Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2DOI 10.20944/preprints202303.0230.v1
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