Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies ARIH2 as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Mar 2026

Armakola Maria, Wilen Anika P, Bustos Bernabe I, Song Pingping, Wang Yi-Zhi, Thomas Adeyemi K, Belur Nandkishore R, Mazzulli Joseph R, Savas Jeffrey N, Kalb Robert G, Krainc Dimitri

Abstract excerpt

Parkinson's disease (PD) is a late-onset neurodegenerative disease characterized by preferential degeneration of midbrain dopaminergic neurons and α-synuclein-containing Lewy bodies that are found in both familial and sporadic forms. Genome-wide association studies (GWAS) have identified many loci associated with risk of sporadic PD, but their role in PD pathogenesis remains largely unknown. We screened a subset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Dopaminergic Neurons

Share to Induced Pluripotent Stem Cells

Share to Parkinson Disease

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 41651665
DOI: 10.1523/JNEUROSCI.0509-25.2026
PMCID: PMC12981288

Genes

ARIH2
TPPP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies ARIH2 as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons.PMID 41651665Read ↗

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease modelSemantic proximity Read ↗

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Semantic proximity Read ↗

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s DiseaseSemantic proximity Read ↗

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During AgingSemantic proximity Read ↗

Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson’s Disease ModelsSemantic proximity Read ↗

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease GenesSemantic proximity Read ↗

Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegansSemantic proximity Read ↗

Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.Semantic proximity Read ↗

Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Modeling Parkinson's Disease in C. elegans.Semantic proximity Read ↗

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegansSemantic proximity Read ↗

CHCHD2 p. Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.