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Article

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

8 Jan 2008

Abstract excerpt

Genomic multiplication of the locus-encoding human alpha-synuclein (alpha-syn), a polypeptide with a propensity toward intracellular misfolding, results in Parkinson's disease (PD). Here we report the results from systematic screening of nearly 900 candidate genetic targets, prioritized by bioinformatic associations to existing PD genes and pathways, via RNAi knockdown. Depletion of 20 gene products reproducibly...

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PMID: 18182484
DOI: 10.1073/pnas.0711018105

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