Article

Ataxin-2 Disordered Region Promotes Huntingtin Protein Aggregation And Neurodegeneration In Drosophila Models Of Huntington’s Disease

2021-10-02

Abstract excerpt

<h4>ABSTRACT</h4> The Ataxin-2 (Atx2) protein contributes to the progression of neurodegenerative phenotypes in animal models of amyotrophic lateral sclerosis (ALS), type 2 spinocerebellar ataxia (SCA-2), Parkinson’s Disease (PD) and Huntington’s Disease (HD). However, because the Atx2 protein contains multiple separable activities, deeper understanding requires experiments to address the exact mechanisms by whic...

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Literature Corpus work: 87cbf65e-3424-5b18-a533-532b3edc0fc3
DOI: 10.1101/2021.10.01.462783

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