Article

Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson’s Disease Models

2022-06-26

Abstract excerpt

Whole exome sequencing of Parkinson’s disease (PD) patient DNA identified single-nucleotide polymorphisms (SNPs) in the TNK2 gene. Although TNK2 encodes a non-receptor tyrosine kinase that has been shown to prevent the endocytosis of the dopamine reuptake transporter (DAT), a causal role for TNK2 in PD remains unresolved. We postulated that specific recessive mutations in patients resulted in aberrant or prolong...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9432f5c9-ba1e-50f3-8192-67ea6feb6272
DOI: 10.1101/2022.06.21.497090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson’s Disease ModelsDOI 10.1101/2022.06.21.497090Read

Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in <i>C. elegans</i>Semantic proximity Read

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegansSemantic proximity Read

Systematic Review of Caenorhabditis elegans Models for Mechanism Research and Drug Discovery in Parkinson’s DiseaseSemantic proximity Read

Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson’s disease, Alzheimer’s disease and autism spectrum disorderSemantic proximity Read

Attenuation of Dopaminergic Neurodegeneration in a <em>C. elegans</em> Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2Semantic proximity Read

Modeling Parkinson's Disease in C. elegans.Semantic proximity Read

Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.Semantic proximity Read

Modelling Parkinson's Disease in C. elegans : Strengths and LimitationsSemantic proximity Read

In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies ARIH2 as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons.Semantic proximity Read

An atfs-1 loss-of-function screen identifies novel regulators of a-synuclein toxicity in C. elegans dopaminergic neuronsSemantic proximity Read

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's diseaseSemantic proximity Read

Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseasesSemantic proximity Read