Article

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory

2023-11-14

Abstract excerpt

Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA modifying enzyme that methylates wobble uridines in specific tRNAs to modulate translation. Through methylation of tRNA-selenocysteine, ALKBH8 promotes selenoprotein synthesis and regulates redox homeostasis. Pathogenic variants in ALKBH8 have been linked to intellectual disability disorders in the human populat...

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Literature Corpus work: a7886757-4aae-5016-be9a-e18cba30d15b
DOI: 10.1101/2023.11.14.566895

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