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Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

19 Aug 2022

Abstract excerpt

The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors have increasingly come into focus, small non-coding RNAs have emerged as an essential component to disease etiology. Using Systemic RNA interference Defective (SID) mutants...

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PMID: 35984862
DOI: 10.1371/journal.pgen.1010115

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