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Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration

15 Oct 2020

Abstract excerpt

In the past few decades, cardiac regeneration has been the central target for restoring the injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide during adulthood. Embryonic and fetal cardiomyocytes undergo robust proliferation to form mature heart chambers in order to accommodate the increased workload of a systemic circulation. In contrast, postnatal cardiomyocytes stop...

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PMID: 33178704
DOI: 10.3389/fcell.2020.594226

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