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Article

AP-1 activation mediates post-natal cardiomyocyte maturation

31 May 2022

Abstract excerpt

AIMS: Post-natal maturation of mammalian cardiomyocytes proceeds rapidly after birth, with most of the myocytes exiting cell cycle, becoming binucleated, and adopting oxidative phosphorylation as the primary metabolic route. The triggers and transcriptional programmes regulating cardiomyocyte maturation have not been fully understood yet. We performed single-cell RNA-Seq in post-natal rat hearts in order to...

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PMID: 35640820
DOI: 10.1093/cvr/cvac088

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