Article

Maturation of human cardiac organoids enables complex disease modelling and drug discovery

2024-09-09

Abstract excerpt

<h4>Summary</h4> Cardiac maturation is an important developmental phase culminating in profound biological and functional changes to adapt to the high demand environment after birth 1,2 . Maturation of human pluripotent stem cell-derived human cardiac organoids (hCO) to more closely resemble human heart tissue is critical for understanding disease pathology. Herein, we profile human heart maturation in vivo 3 t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3264cbfd-cd57-5c96-9d9c-a72a2cf7a5a7
DOI: 10.1101/2024.09.05.611336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Maturation of human cardiac organoids enables complex disease modelling and drug discoveryDOI 10.1101/2024.09.05.611336Read

Maturation of human cardiac organoids enables complex disease modeling and drug discoverySemantic proximity Read

Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read

Adapting to a new environment: postnatal maturation of the human cardiomyocyteSemantic proximity Read

Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric MyocardiumSemantic proximity Read

A patterned human heart tube organoid model generated by pluripotent stem cell self-assemblySemantic proximity Read

Enhanced iPSC Cardiomyocyte Maturation via Combined 3D-Culture and Metabolic CuesSemantic proximity Read

Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read

Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturationSemantic proximity Read

The long and winding road of cardiomyocyte maturation.Semantic proximity Read

High cardiomyocyte diversity in human early prenatal heart developmentSemantic proximity Read

Metabolically-Driven Maturation of hiPSC-Cell Derived Cardiac ChipSemantic proximity Read

Non-Cardiomyocytes Influence the Electrophysiological Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes During DifferentiationSemantic proximity Read