Article

Adult Human Heart ECM Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

2023-11-01

Abstract excerpt

Myocardial infarction can lead to the loss of billions of cardiomyocytes, and while cell-based therapies are a promising option, the immature nature of in vitro-generated human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) is a significant roadblock to their development. Through the years, various approaches have emerged to improve iCM maturation, yet none could fully recapitulate the complexi...

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Literature Corpus work: 8b7a64b4-2d94-5c2d-ae01-bf406cff76fb
DOI: 10.1101/2023.10.31.565062

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