Article

TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders

2018-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Genetic signal detection in genome-wide association studies (GWAS) is enhanced by pooling small signals from multiple Single Nucleotide Polymorphism (SNP), e.g. across genes and pathways. Because genes are believed to influence traits via gene expression, it is of interest to combine information from expression Quantitative Trait Loci (eQTLs) in a gene or genes in the same pathway. Such methods,...

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Literature Corpus work: efdca551-0ac5-5a40-bced-9fe202bd6a6c
DOI: 10.1101/373050

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