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Article

Integrating eQTL data with GWAS summary statistics in pathway-based analysis with application to schizophrenia.

Genetic epidemiology - 1 Apr 2018

Wu Chong, Pan Wei

Abstract excerpt

Many genetic variants affect complex traits through gene expression, which can be exploited to boost statistical power and enhance interpretation in genome-wide association studies (GWASs) as demonstrated by the transcriptome-wide association study (TWAS) approach. Furthermore, due to polygenic inheritance, a complex trait is often affected by multiple genes with similar functions as annotated in gene pathways....

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PMID: 29411426
DOI: 10.1002/gepi.22110
PMCID: PMC5851843

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