TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.

doi:10.1002/ajmg.b.32823

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Article

TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2020

Chatzinakos Chris, Georgiadis Foivos, Lee Donghyung, Cai Na, Vladimirov Vladimir I, Docherty Anna, Webb Bradley T, Riley Brien P, Flint Jonathan, Kendler Kenneth S, Daskalakis Nikolaos P, Bacanu Silviu-Alin

Abstract excerpt

Genetic signal detection in genome-wide association studies (GWAS) is enhanced by pooling small signals from multiple Single Nucleotide Polymorphism (SNP), for example, across genes and pathways. Because genes are believed to influence traits via gene expression, it is of interest to combine information from expression Quantitative Trait Loci (eQTLs) in a gene or genes in the same pathway. Such methods, widely...

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PMID: 32954640
DOI: 10.1002/ajmg.b.32823
PMCID: PMC7756231

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