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Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks.

Scientific reports - 14 Jun 2017

Zhao Huiying, Nyholt Dale R, Yang Yuanhao, Wang Jihua, Yang Yuedong

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified single variants associated with diseases. To increase the power of GWAS, gene-based and pathway-based tests are commonly employed to detect more risk factors. However, the gene- and pathway-based association tests may be biased towards genes or pathways containing a large number of single-nucleotide polymorphisms (SNPs) with small P-values caused...

Topics

Breast Neoplasms
Computational Biology
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Schizophrenia

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28615668
DOI: 10.1038/s41598-017-03826-2
PMCID: PMC5471232

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