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Article

TIPS: a novel pathway-guided joint model for transcriptome-wide association studies.

Briefings in bioinformatics - 23 Sept 2024

Wang Neng, Ye Zhenyao, Ma Tianzhou

Abstract excerpt

In the past two decades, genome-wide association studies (GWAS) have pinpointed numerous SNPs linked to human diseases and traits, yet many of these SNPs are in non-coding regions and hard to interpret. Transcriptome-wide association studies (TWAS) integrate GWAS and expression reference panels to identify the associations at gene level with tissue specificity, potentially improving the interpretability. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39550224
DOI: 10.1093/bib/bbae587
PMCID: PMC11568880

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