Article

LDAK-PBAT: A Pathway-Based Analysis Tool for Decoding the Genetics of Complex Diseases

2025-01-16

Abstract excerpt

We introduce LDAK-PBAT, a novel tool for detecting gene pathways associated with complex traits. LDAK-PBAT tests pathways for significance using a heritability-based framework that controls for both the contributions of genes not in the pathway and of inter-genic SNPs. LDAK-PBAT is computationally efficient, requiring only GWAS summary statistics and a reference panel, and when applied to human traits, can test 10...

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Literature Corpus work: 7836c636-ae7b-5535-b031-4f6d26b7f6e0
DOI: 10.1101/2025.01.15.25320628

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