Article
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.
Molecular cancer therapeutics - 1 Dec 2014
Ott Heidi M, Graves Alan P, Pappalardi Melissa B, Huddleston Michael, Halsey Wendy S, Hughes Ashley M, Groy Arthur, Dul Edward, Jiang Yong, Bai Yuchen, Annan Roland, Verma Sharad K, Knight Steven D, Kruger Ryan G, Dhanak Dashyant, Schwartz Benjamin, Tummino Peter J, Creasy Caretha L, McCabe Michael T
Abstract excerpt
The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27). Recently, EZH2 mutations have been reported at Y641, A677, and A687 in non-Hodgkin lymphoma. Although the Y641F/N/S/H/C and A677G mutations exhibit clearly increased activity with substrates dimethylated at lysine 27 (H3K27me2), the A687V mutant has been shown to prefer a monomethylated lysine 27 (H3K27me1)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.