Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.

Journal of the American Chemical Society - 1 Oct 2014

Brown Zachary Z, Müller Manuel M, Jain Siddhant U, Allis C David, Lewis Peter W, Muir Tom W

Abstract excerpt

The histone methyltransferase PRC2 plays a central role in genomic stability and cellular development. Consequently, its misregulation has been implicated in several cancers. Recent work has shown that a histone H3 mutant, where the PRC2 substrate residue Lys27 is replaced by methionine, is also associated with cancer phenotypes and functions as an inhibitor of PRC2. Here we investigate the mechanism of this PRC2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Inhibitors
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Kinetics

Share to Models, Molecular

Share to Mutation

Share to Neoplasms

Share to Polycomb Repressive Complex 2

Source

Open in PubMed Open full text

Identifiers

PMID: 25180930
DOI: 10.1021/ja5060934
PMCID: PMC4183613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.PMID 25180930Read ↗

Regulation of histone methylation by automethylation of PRC2Semantic proximity Read ↗

In situ chromatin interactomics using a chemical bait and trap approach.Semantic proximity Read ↗

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.Semantic proximity Read ↗

Reaction coupling between wild-type and disease-associated mutant EZH2.Semantic proximity Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatinSemantic proximity Read ↗

Structure of the PRC2 complex and application to drug discovery.Semantic proximity Read ↗

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.Semantic proximity Read ↗

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.Semantic proximity Read ↗

Enzyme-dependent lysine deprotonation in EZH2 catalysis.Semantic proximity Read ↗

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer TherapySemantic proximity Read ↗

Tracking chromatin state changes using <i>μ</i> Map photo-proximity labelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.