Article
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012
McCabe Michael T, Graves Alan P, Ganji Gopinath, Diaz Elsie, Halsey Wendy S, Jiang Yong, Smitheman Kimberly N, Ott Heidi M, Pappalardi Melissa B, Allen Kimberly E, Chen Stephanie B, Della Pietra Anthony, Dul Edward, Hughes Ashley M, Gilbert Seth A, Thrall Sara H, Tummino Peter J, Kruger Ryan G, Brandt Martin, Schwartz Benjamin, Creasy Caretha L
Abstract excerpt
Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the polycomb repressive complex 2 and is overexpressed in many cancers. In B-cell lymphomas, its substrate preference is frequently altered through somatic mutation of the EZH2 Y641 residue. Herein, we identify mutation of EZH2 A677 to a glycine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.