Article
LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.
Molecular cell - 16 Jul 2026
Ramage Dylan E, Wieske Lianne H E, Crowe Charlotte, Christensen Jens B, von Wilmowski Theo A, Bannister Zoe, Grant Drew W, Nakasone Mark A, Haubrich Kevin, Dorward Mark, Tchasovnikarova Iva A, Weekes Michael P, Matheson Nicholas J, Bayin N Sumru, Ciulli Alessio, Timms Richard T
Abstract excerpt
Adaptation to fluctuating nutrient supply is essential for organismal survival, but how human cells monitor the abundance of many critical nutrients remains undefined. Characterizing the conditional degradation of CDO1, the critical enzyme responsible for cysteine catabolism, here we identify a Cullin-RING E3 ligase complex defined by the substrate adaptor LRRC58 that is sensitive to cysteine abundance. When...
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