Article

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugases

2021-02-16

Abstract excerpt

<h4>SUMMARY</h4> Nutrient copper supply is critical for cell growth and differentiation, and its disturbance is associated with major pathologies including cancer and neurodegeneration. Although increasing copper bioavailability in late Precambrian facilitated emergence of novel cuproproteins, their intricate regulation by this essential trace element remains largely cryptic. We found that subtle rises in cellula...

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Literature Corpus work: 49c6bef5-13ff-5671-a485-7518f226352c
DOI: 10.1101/2021.02.15.431211

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