Article

HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency

2024-06-06

Abstract excerpt

<h4>ABSTARCT</h4> The maintenance of a properly folded proteome is critical for cellular function and organismal health, and its age-dependent collapse is associated with a wide range of diseases. Here, we find that despite the central role of Coenzyme A as a molecular cofactor in hundreds of cellular reactions, limiting Coenzyme A levels in C. elegans and in human cells, by inhibiting the conserved pantothenate...

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Literature Corpus work: 2d01b0f7-d0f0-5230-a707-76d596ded89e
DOI: 10.1101/2024.06.05.597553

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