Article

A Probabilistic Approach to Estimate the Temporal Order of Pathway Mutations Accounting for Intra-Tumor Heterogeneity

2024-01-11

Abstract excerpt

The development of cancer involves the accumulation of somatic mutations in a number of key biological pathways. Delineating the order of pathway mutations during tumorigenesis is very important to understand biological mechanisms of cancer development and to inform new therapeutic targets. A number of statistical and computational methods have been proposed for estimating the order of somatic mutations based on m...

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Literature Corpus work: ef61edb9-7232-5583-b336-83f9067a86fc
DOI: 10.21203/rs.3.rs-3833734/v1

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