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Article

The temporal order of genetic and pathway alterations in tumorigenesis.

PloS one - 1 Jan 2011

Gerstung Moritz, Eriksson Nicholas, Lin Jimmy, Vogelstein Bert, Beerenwinkel Niko

Abstract excerpt

Cancer evolves through the accumulation of mutations, but the order in which mutations occur is poorly understood. Inference of a temporal ordering on the level of genes is challenging because clinically and histologically identical tumors often have few mutated genes in common. This heterogeneity may at least in part be due to mutations in different genes having similar phenotypic effects by acting in the same...

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Identifiers

PMID: 22069497
DOI: 10.1371/journal.pone.0027136
PMCID: PMC3206070

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