pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Progression Dynamics

Abstract excerpt

High-throughput sequencing technologies have facilitated the generation of an unprecedented amount of genomic cancer data, opening the way to a more profound understanding of tumorigenesis. In this endeavor, two fundamental questions have emerged, namely (1) which alterations drive tumor progression and (2) in which order do they occur? Answering these questions is crucial for therapeutic decisions involving...

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