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Article

A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis.

BMC bioinformatics - 2 Dec 2019

Wang Menghan, Yu Tianxin, Liu Jinpeng, Chen Li, Stromberg Arnold J, Villano John L, Arnold Susanne M, Liu Chunming, Wang Chi

Abstract excerpt

BACKGROUND: Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new therapeutic targets. Although a number of statistical and computational methods have been proposed to estimate the temporal...

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Identifiers

PMID: 31791231
DOI: 10.1186/s12859-019-3218-2
PMCID: PMC6889196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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