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Article

Uncovering the subtype-specific temporal order of cancer pathway dysregulation.

PLoS computational biology - 1 Nov 2019

Khakabimamaghani Sahand, Ding Dujian, Snow Oliver, Ester Martin

Abstract excerpt

Cancer is driven by genetic mutations that dysregulate pathways important for proper cell function. Therefore, discovering these cancer pathways and their dysregulation order is key to understanding and treating cancer. However, the heterogeneity of mutations between different individuals makes this challenging and requires that cancer progression is studied in a subtype-specific way. To address this challenge,...

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Identifiers

PMID: 31710622
DOI: 10.1371/journal.pcbi.1007451
PMCID: PMC6872169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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