Article

Identifying Restrictions in the Order of Accumulation of Mutations during Tumor Progression: Effects of Passengers, Evolutionary Models, and Sampling

2014-05-27

Abstract excerpt

Cancer progression is caused by the sequential accumulation of mutations, but not all orders of accumulation of mutations are equally likely. When the fixation of some mutations depends on the presence of previous ones, identifying restrictions in the order of accumulation of mutations can lead to the discovery of therapeutic targets and diagnostic markers. Using simulated data sets, I conducted a comprehensive co...

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Literature Corpus work: e62ed339-5fe7-5ebe-9f4e-0532eb1cc269
DOI: 10.1101/005587

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