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Article

Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes.

BMC medical genomics - 20 Apr 2018

Rhee Je-Keun, Kim Tae-Min

Abstract excerpt

BACKGROUND: It is well recognized that accumulation of somatic mutations in cancer genomes plays a role in carcinogenesis; however, the temporal sequence and evolutionary relationship of somatic mutations remain largely unknown. METHODS: In this study, we built a population-based statistical framework to infer the temporal sequence of acquisition of somatic mutations. Using the model, we analyzed the mutation...

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Identifiers

PMID: 29697365
DOI: 10.1186/s12920-018-0352-z
PMCID: PMC5918460

Genes

APC
EGFR
KRAS
NOTCH1
PTEN

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