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Article

Estimating the order of mutations during tumorigenesis from tumor genome sequencing data.

Bioinformatics (Oxford, England) - 15 Jun 2012

Youn Ahrim, Simon Richard

Abstract excerpt

MOTIVATION: Tumors are thought to develop and evolve through a sequence of genetic and epigenetic somatic alterations to progenitor cells. Early stages of human tumorigenesis are hidden from view. Here, we develop a method for inferring some aspects of the order of mutational events during tumorigenesis based on genome sequencing data for a set of tumors. This method does not assume that the sequence of driver...

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Identifiers

PMID: 22492649
DOI: 10.1093/bioinformatics/bts168
PMCID: PMC3465102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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